Matrix protein 1: A comparative in silico study on different strains of influenza A H5N1 Virus
نویسندگان
چکیده
The importance of influenza viruses as worldwide infectious agents is well recognized. Specific mutations and evolution in influenza viruses is difficult to predict. We studied specific mutations in matrix protein 1 (M1) of H5N1 influenza A virus together with properties associated with it using prediction tools developed in Bioinformatics. Changes in hydrophobicity, polarity and secondary structure at the site of mutation were noticed and documented to gain insight towards its infection.
منابع مشابه
Designing of A Multi-epitope Recombinant Protein, Consisting of Several Conserved Epitopes from Hemagglutinin Protein of the H1N1 and H5N1 Strains of Influenza Virus by Immunoinformatics Approaches
Introduction: According to marked advances in bioinformatics studies, development of influenza vaccines has been greatly modified in many studies. In this study, we have designed a multi-epitope recombinant protein, consisting of several conserved epitopes from Hemagglutinin protein of the H1N1 and H5N1 strains of Influenza virus by immunoinformatics approaches. Materials and Methods: The regis...
متن کاملExpression of HA1 antigen of H5N1 influenza virus as a potent candidate for vaccine in bacterial system
The impending influenza virus pandemic requires global vaccination to prevent large-scale mortality and morbidity, but traditional influenza virus vaccine production is too slow for rapid responses. In this study, bacterial system has been developed for expression and purification of properly folded HA1 antigen as a rapid response to emerging pandemic strains. Here, a recombinant H5N1 (A/Indone...
متن کاملConstruction of chimeric protein 3M2e.FliC and its immunoinformatics analyses and expression in Bacillus subtilis
Introduction: Influenza A virus causes unpredictable epidemics and pandemics by creating antigenic variations. With the appearance of each new strain, rapid emergency countermeasures are taken against this new strain. Hence, designing an applicable and cross protective strategy to counter this virus is of great importance. To achieve this, choosing conserved antigenic regions in influenza virus...
متن کاملMortality of wild swans associated with naturally infection with highly pathogenic H5N1 avian influenza virus in Iran
In the February 2006 in two wetlands in northern Iran, the mortality among wild swans was observed. Paralysis was the most prominent feature of the disease. Histologically, diffused necrosis of acinar cells in pancreas, degeneration and necrosis of some neurons in central nervous system (CNS), sever necrotic and hemorrhagic enteritis, foci of haemorrahge and myocardial cell necrosis in the he...
متن کاملBacillus subtilis as a Host for Recombinant Hemagglutinin Production of the Influenza A (H5N1) Virus
Abstract Background and Aims: Influenza A(H5N1) viruses circulating in animals might evolve and acquire the ability to spread from human to human and thus start a pandemic. Hemagglutinin (HA) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. Recent studies have shown that...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Bioinformation
دوره 1 شماره
صفحات -
تاریخ انتشار 2006